The minimum purity of the technical material is 970 g/kg. It is noted that the metabolites 4’‐OH‐PYR and PYPAC have very low to moderate persistence (max. Mahan Pyriproxyfen 10% EC. However, for uses of pyriproxyfen on other crops than the representative uses considered here, the importance of anaerobic conditions would need to be re‐evaluated and metabolites formed under anaerobic conditions might need to be addressed further. A low in‐field risk to A. rhopalosiphi and Orius laevigatus was concluded for the representative use in pome fruit. Based on available genotoxicity studies (in vitro and in vivo), it was concluded that pyriproxyfen is not genotoxic. Pyriproxyfen is the ISO common name for 4‐phenoxyphenyl (RS)‐2‐(2‐pyridyloxy)propyl ether (IUPAC), only produced as a racemate. ca. However, the ecotoxicological profile of this metabolite was compared with that of the parent molecule that indicated that the metabolite has a comparable or lower toxicity than the parent (this assessment included data on arthropods and other invertebrates). Any insect population may contain individuals naturally resistant to PYRIPROXYFEN 100EC and any other group code 7C insecticide. High risk is indicated for the soilless greenhouse use in ornamentals and for walk‐in tunnels (open). It is noted that the relative toxicity and possible preferential metabolism of the enantiomers was not investigated, however, considering the high margin between worker and bystander exposure and the AOEL/AAOEL, it is considered unlikely that the reference values would be exceeded even if a complete shift would occur after application to a potentially more toxic enantiomer. On the basis of the available data and risk assessment, low risk to earthworms and other soil macroorganisms, soil microorganisms, non‐target terrestrial plants and organisms in sewage treatment plants was concluded for all the representative uses. Agrotechnica is an integrated company that provides complete service of manufacturing, formulation and packing of Crop Protection Products, with a marketing position in the Greek Crop Protection Industry the last 50 years. The resistant individuals can eventually dominate the insect population if these insecticides are used repeatedly. It was concluded that the adsorption of pyriproxyfen and its metabolites was not pH dependent. High chronic risk to fish cannot be excluded for the outdoor uses in citrus and pome fruit (late) using FOCUS Step 4, and in walk‐in tunnels (open), and also for greenhouse soilless uses in ornamentals. Pyriproxyfen exhibited a low acute toxicity when administered orally, dermally or by inhalation in rats or mice. ha-1, beneath the tagged twigs in order to assess the reduction of thiamethoxam 25% WDG @ 50 g a.i. and therefore, a low risk cannot be concluded from exposure via the sediment (data gap and that could not be finalised). The metabolism study on cucumbers with direct application to the surface of the leaves and fruits can be considered as supportive data and showed a similar metabolic pattern, besides the parent compound (up to 38% TRR), 4’‐OH‐PYR (free and conjugated) and POPA compounds accounted for maximum 17% TRR and 11.5% TRR, respectively, in cucumber fruit. conc. The rates of dissipation and degradation in the environmental matrices investigated were estimated using FOCUS (2006) kinetics guidance. LEONIS is a premix insecticide having Pyriproxyfen 10%+Bifenthrin 10%EC. It should be noted that there are CIPAC methods for determination of the active substance in the technical material (CIPAC 715/TC/M/‐) and in the formulation (CIPAC 715/EC/M/‐). Therefore, the data from the available indoor microcosm study were further considered and a low risk to aquatic sediment‐dwellers can be only concluded for the outdoor uses in citrus, and pome fruit (late and early application) with appropriate mitigation. Finally, for the workers performing harvesting activities in the different crops, no PPE was required according to the EFSA model. In cotton seed and gin trash, pyriproxyfen was found at ca. It is an Insect Growth Regulator (IGR) It controls all the stages of Whitefly i.e. PYRIPROXYFEN 10% EC use can limit insect reproduction by causing adult insect sterilization, reduced egg production, behavior modifications, deformed insects and death. buffer zones and/or spray drift reduction (FOCUS Step 4). The PECsw values at FOCUS Step 4 were less than the ETO‐RAC for all the outdoor representative uses, whereas high risk was concluded for the soil‐less greenhouse use in ornamentals and walk‐in tunnels (open). Pyriproxyfen was predominant in apples, tomatoes and oranges (45–68% total radioactive residue (TRR)) and the metabolites 4’‐OH‐PYR free in apples at 11% TRR (0.021 mg eq/kg) and PYPA (free and conjugated) in tomatoes at 11% TRR (0.03 mg eq/kg) were also recovered. Refer to experts’ consultation 2.4 in the Report of Pesticides Peer Review Experts’ Meeting 190 (EFSA, 2019). However, a high risk to T. pyri could not be excluded. Action: Insecticide. 4’‐OH‐PYR was detected in mouse and hen metabolism studies and the available data indicate that 4’‐OH‐PYR was covered in the mammalian and avian toxicity studies with the parent.99 In poultry, pyriproxyfen was predominant in eggs, muscle and fat (46–94% TRR). Scale insects are no match for the powerful, pyriproxyfen-based Reemit™ 0.86 EC from Atticus. An issue is also listed as a critical area of concern if, in the light of current scientific and technical knowledge using guidance documents available at the time of application, the active substance is not expected to meet the approval criteria provided for in Article 4 of Regulation (EC) No 1107/2009. In a 21‐day dermal study with rats, no local or systemic effects were observed up to the highest dose tested. Based on standard laboratory studies, a high chronic risk to aquatic invertebrates was indicated for all the representative uses at FOCUS Step 3 & 4, with the exception of walk‐in tunnels (closed) for which low risk was indicated at Step 3. Based on the regulatory studies submitted for pyriproxyfen together with the publications from the literature review where a link of pyriproxyfen to microcephaly was reported, the experts agreed that there was no indication of a link between the active substance and the finding of microcephaly. With the exception for the acute risk for the representative use on citrus, these calculations also indicated that a high risk to solitary bees cannot be excluded for the representative uses on citrus, pome fruits and tomato (outdoor use). Mrls for animal products were not impaired: simplified molecular‐input line‐entry system ; InChiKey: Union! Level of 5 g/kg the simulations particular conditions are not required for products of animal origin )... Scale insects are no match for the individual isomers nor requested only very few soil collected. Other group code 7C insecticide L and a significant fraction of radioactive residues being associated with proteins adverse effects Hind! 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