This study showed that the percutaneous absorption of Zn from Zn 2-pyrrolidone 5-carboxylate- containing emulsion was more than from the two others ones. Nausea, vomiting, diarrhea, and temporary pruritus have been described as side effects of oral Zn supplementation [28,58], which are fleeting and dose dependent [8]. Fever, malaise, dizziness, headaches, anemia and even death are seen in cases of overdose [46]. They probably are effective in preventing cancer induction by decreasing oxidative stress and improving immunity functions [2,60]. Drugs dermatology 3:565, 2OO4): Increase in size of seborrheic keratosis which can be seen after the use of cytarabene for the the treatment of acute myelogenous leukemia. Wuehler SE, Peerson JM, Brown KH (2005) Use of national food balance data to estimate the adequacy of zinc in national food supplies: methodology and regional estimates. Naginiene R, Kregzdyte R, Abdrakhmanovas A, Ryselis S (2004) Assay of trce elements, thyroid gland and blood indices in children with alopecia. Theocharis SE, Margeli AP, Klijanienko JT, Kouraklis GP (2004) Metallothionein expression in human neoplasia. Reding P, Duchateau J, Bataille C (1984) Oral zinc supplementation improves hepatic encephalopathy. 2014;2014 DOI 10.1155/2014/709152 . Indexed on: 12 Oct '12 Published on: 12 Oct '12 in Clinical, cosmetic and investigational dermatology However, zinc may be considered as an adjunctive treatment modality. Clipboard, Search History, and several other advanced features are temporarily unavailable. body as well as tbe skin. Zinc Sulphate should … Turk J Med Sci. Feb 12, 2016 - Download professional and editable dermatology powerpoint (ppt) template and background for dermatology ppt presentations. This section of the website hosts Free Dermatology PowerPoint Templates and free Skincare PowerPoint templates specially designed for doctors, academicians, students and other professionals, who often need to create PowerPoint presentations on Dermatology … Cases in Dermatology Annual Primary Care Conference June 5, 2015 Chong Foo, M.D. Measures to avoid and reduce contact with house dust mites (HDM) may be helpful in patients with high sensitivity to HDM. The liver plays an important role in its homeostasis [2]. The WHO- recommended intake of Zn is 10-15 mg for adults and 5 mg for infants. [Zinc in dermatology]. Sharquie KE, Najim RA, Al-Hayani RK, Al-Nuaimy AA, Maroof DM (2008) The therapeutic and prophylactic role of oral zinc sulfate in management of recurrent aphthous stomatitis (ras) in comparison with dapsone. Abramovits W (1979) Dermatology-epitomes of progress: a capsule on zinc. Zinc is also involved in melanogenesis, fatty acids and vitamin A and E metabolism. Zinc Therapy in Dermatology. Zinc responsive dermatosis. In this disorder, a defect in Zn utilization or uptake at a cellular level has been hypothesized [45]. Comparison of Calcium Phosphate and Zinc Oxide Nanoparticles as Dermal Penetration Enhancers for Albumin. Introduction. Acrodermatitis enteropathica This syndrome results from inadequate absorption or dietary intake of zinc. Although many human body organs are affected by severe Zn deficiency, such as the immune, central nervous, gastrointestinal, reproductive, integumentary and reproductive systems [2], the skin is commonly involved and is often one of the first organs affected by this deficiency [3]. Zn supplementations can reduce the absorption of iron, tetracycline, penicillamine and quinolone [28]. King JC, Shames DM, Woodhouse LR (2000) Zinc homeostasis in humans. Additionally, sample collection and laboratory techniques are important for assessing serum Zn. Additionally, hepatic encephalopathy due to the liver failure is associated with the Zn deficiency [2]. (2012) Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency. It is characterized by acquired, idiopathic, progressive and circumscribed hypomelanosis on different parts of the body. It is expressed in the nervous system, myocardium, skeletal muscle, and basal aspect of the stratified embryonic epithelia. In this article, we collected and summarized the appropriate manuscripts and papers regarding the importance of Zn and its pharmacokinetics in human beings, causes and manifestations of its deficiency and excess, its therapeutic roles, side effects of Zn supplements and ways for its prevention and treatment. The role of Zn in human immunity has been summarized in Scheme-1. This result can be useful for the rapid, qualitative and quantitative monitoring of the hair pigmentation changes [40]. It also has roles in pathogenesis of some dermatological disorders. Vitamin C insufficiency results in hair shaft abnormality (cork screw hairs). All of the Zn transporters have trans-membrane domains and are encoded by 2 solute-linked carrier (SLC) gene families. 2. In addition to skin pathologies that are clearly zinc-dependent, … [Crossref] 46. Zn is a metal moiety of many enzymes and is essential for normal cellular functions. Indications for zinc supplementation. He was asked to evaluate an otherwise largely healthy-appearing female patient with a dry, desquamative eruption with a predilection for sites of friction. Using topical and oral formulation of zinc works in managing cases of … Keratolytics soften and facilitate exfoliation of epidermal cells. According to the recommended regimen by the WHO, dietary intake of Zn is enough to maintain Zn levels within a normal range, except if there is abnormality in the gastrointestinal or urinary losses [10]. Download Share --> Share. (2010) Symptomatic acquired zinc deficiency in at-risk premature infants: high dose preventive supplementation is necessary. Cytarabene causes inflammation of existing seborrheic keratosises 57. The Adobe Flash plugin is needed to view this content. Pseudo sign of Leser Trelat (Patton et al J. doi: 10.4317/medoral.19896. (2012) Disseminated lichen planus due to a zinc allergy. Zinc in skin pathology and care. Ito Y, Saito K, Hatano Y, Goto M, Takahashi A, et al. In this article, the importance of zinc in human biology and physiology, its pharmacokinetics, causes and manifestations of its deficiency and excess, its therapeutic roles, side effects of zinc supplements and ways for its prevention and treatment have been described. Pediatric Dermatology: Bumps and Lumps Shoni Rozenberg, DO* Suzanne Sirota Rozenberg, DO, FAOCD** *OGME 3, St John’s Episcopal Hospital Dermatology Program, Queens, NY **Program Director, St John’s Episcopal Hospital Dermatology Program Queens, NY. It is an essential trace element important for a large number of structural proteins, enzymatic processes and transcription factors [2]. These advances led to the discovery of Zn, vitamin C, and many other essential components [7]. Stefani M, Bottino G, Fontenelle E, Azulay DR (2009) Efficacy comparison between cimetidine and zinc sulphate in the treatment of multiple and recalcitrant warts. OA Textâs journals are led by prominent researchers, each embracing the concept that basic knowledge can foster sustainable solutions for society. Zinc presentation (1) 1. Kappus H, Reinhold C (1994) Heavy metal-induced cytotoxicity to cultured human epidermal keratinocytes and effects of antioxidants. ments, topical therapies are the most important treatments in dermatology. 2015 Nov-Dec;77(6):694-704. doi: 10.4103/0250-474x.174989. 2007 Sep-Oct;24(5):536-40. doi: 10.1111/j.1525-1470.2007.00512.x. Can Vet J 46: 555-557. COVID-19 is an emerging, rapidly evolving situation. The eruption that is pictured here may be preceded by blisters. Cohen JB, Janniger CK, Piela Z, Szepietowski JC, Samady JA, et al. In the moderate forms, it results in growth retardation, and hypogonadism in male adolescents, rough skin, poor appetite, neurologic dysfunction, mental lethargy, delayed healing of wound, and cell-mediated immunity dysfunction. USA.gov. In this disorder, thymic atrophy is a consequence; hence, thymocytes and immune cell functions are deprived [28]. Serum zinc levels in seborrheic dermatitis: a case-control study. Henkel RR, Defosse K, Koyro HW, Weissmann N, Schill WB (2003) Estimate of oxygen consumption and intracellular zinc concentration of human spermatozoa in relation to motility. Zn is involved in important functional activities in the hair follicles [9]. Yanagi T, Kodama K, Yoshihisa Y, Shimizu H, Shimizu T (2006) Macrophage migration inhibitory factor in zinc-allergic systemic contact dermatitis. Academia.edu is a platform for academics to share research papers. 2015 Mar 1;20(2):e180-7. These syndromes can be reversed with systemic zinc repletion. Until the mid 20th century, the importance of Zn in the growth and development of mammals was not recognized. (2004) Zinc finger protein Zac1 is expressed in chondrogenic sites of the mouse. zinc, function, treatment, pathogenesis, dermatology. In addition, Zn, via regulating of the metallothionein expression, is effective in the intracellular Zn compartmentalization [2,25] and antioxidant function [2,26,27]. Formulations used in this study increased the Zn concentration in the whole skin and epidermis [47]. Presentations. It plays main roles in the cell-mediated immunity, bone formation, tissue growth, brain function, growth of the fetus and child. In addition, it potently inhibits hair follicle regression and accelerates hair follicle recovery [9,36,37]. 1)Both conditions began simultaneously (neoplasia and paraneoplasia) 2) Development of a parallel course * … Henkel R, Bittner J, Weber R, Hüther F, Miska W (1999) Relevance of zinc in human sperm flagella and its relation to motility. Elemental Zn in pharmacological doses of 4 to 12 mg/kg/day can result in gastroenteritis, gastrointestinal bleeding, microcytosis, relative neutropenia, hypoceruloplasminemia, and in prolonged use, anemia secondary to Cu deficiency [28,58]. Global Dermatology Drugs Market Demand and Business Growth Opportunity 2020 - A recent report published by The Business Research Company on Dermatology Drugs Market provides in-depth analysis of segments and sub-segments in the global as well as regional. INTRODUCTION • Zinc, a divalent cation, Atomic no-30 • Essential micro-nutrient •Role of zinc- Over 300 metalloenzymes and over 2000 transcription for regulation of lipid, protein and nucleic acid metabolism, and gene transcription. Dietary Zn binds strongly to proteins near the natural PH [2]. In human beings, zinc (Zn) constitutes less than 0.005% of total body weight, and is present in all types of cells [1]. In the catalytic role, Zn is a critical component of hundreds of the metalloenzymes [2,8,20], such as alkaline phosphatase, carbonic anhydrase, pancreatic carboxypeptidases, RNA polymerases [2], alcohol dehydrogenase [2,9], DNA and RNA nucleotidyl transferases, glutamic, lactic and malic dehydrogenase and δ-aminolevulinic acid dehydratase [9]. In the early 1900s when advances in biochemistry appeared, many of the essential constituents of nutrition were introduced. Hall J1 (2005) Diagnostic dermatology. 3 I/ LA DERMATOLOGIE ET LE DERMATOLOGUE 1/ La dermatologie : Le champ d’activité de la dermatologie est vaste puisqu’il englobe la peau mais aussi les ongles, le cuir chevelu et les muqueuses Il s’étend à l’allergologie (science des allergies) et à l’esthétique pour corriger certaines imperfections provoquées par l’âge, le soleil ou les séquelles de certaines maladies de peau The activity of serum alkaline phosphatase is moderately sensitive indicator of the Zn status because its activity remains close to normal unless there is excessive and prolonged deficiency [28]. Glob Dermatol 3: doi: 10.15761/GOD.1000185, Dermatologist at Dr. Nooshin Bagheranâs office, Taha Physiciansâ building, P.O.Box: 6414715878, Khoramshahr, Khuzestan Province, Iran. Guéniche A, Viac J, Lizard G, Charveron M, Schmitt D (1995) Protective effect of zinc on keratinocyte activation markers induced by interferon or nickel. Disease : Route of administration: Efficacy: Reference number: Warts : Topical : Efficacious as 5%, 10% zinc sulphate lotion, 20% zinc oxide paste, and 2% intralesional zinc sulphate injection. Journal Homepage. Chodorowska G, Lecewicz-Torun B, Wiercinski J (1990) Study of the zinc content of hair and serum in selected skin diseases. In an in vitro study, Priot et al showed that Zn absorption was poor through normal human skin independent of the vehicle used [48]. Further research is needed to establish the indications for zinc treatment in dermatology, optimal mode of zinc delivery, and best type of zinc compound to be used. Environmental modifications are not supported by the currently available data and more studies are needed. Acrodermatitis entropathica is an autosomal recessive inherited disease resulting from a mutation in the Zip4 transporter [2,50]. In animals, it has been shown that Zn supplementation may prevent both acute and chronic alcohol- induced liver injuries [2]. Zn administered in dental restoration can cause oral LP, palmoplantar pustulosis, a maculopapular rash, and systemic contact dermatitis [19]. Yoshihisa Y, Shimizu T (2012) Metal allergy and systemic contact dermatitis: an overview. Androgenetic alopecia has been associated with lower iron and vitamin D levels. Zinc, elemental or in its various forms (salts), has been used as a therapeutic modality for centuries. In the structural role, Zn coordinates with certain protein domains, resulting in protein folding and producing structures such as "Zn fingers" [2,20]. They also play important roles in both Ca signaling and Zn homeostasis. Lee SY, Nam KS, Seo YW, Lee JS, Chung H (1997) Analysis of serum zinc and copper levels in alopecia areata. BY DR SIDDHI TIWARI MODERATOR : DR SAROJ PUROHIT 2. Zacl is a Zn finger transcription factor that functions as a potential tumor suppressor gene and has anti-proliferative activity. 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